Four major groups of drugs:

• Magnesium
• Parkinson's disease medications
• Sedatives
• Narcotics

Sleep study will confirm sleep disturbed by PLMS 

trial periods without drugs every 6 - 12 months check that the drugs are still needed. 

AND minimises risk of the development of tolerance to the drug & risk of abuse [narcotics]

Domperidone is the only anti-nausea drug that does not bother RLS 

Magnesium is helpful in 50% eg.Magnesium Orotate 200 mg half an hour before sleep